A combination drug is a fixed-dose combination (FDC) that includes two or more active pharmaceutical ingredients (APIs) combined in a single dosage form, which is manufactured and distributed in fixed doses. Terms like "combination drug" or "combination drug product" can be common shorthand for a FDC product (since most combination drug products are currently FDCs), although the latter is more precise if in fact referring to a mass-produced product having a predetermined combination of drugs and respective dosages (as opposed to customized polypharmacy via compounding). See also. We'll be back as soon as we can! We're sorry for the inconvenience.. 184 no. In addition to simply being a means of facilitating the general advantages of combination therapy, specific advantages of fixed-dose combination (FDC) drug products include:. Ability to compose combined profiles of for example pharmacokinetics, effects and adverse effects that may be specific for the relative dosages in a given FDC product, providing a simpler overview compared to when looking at the profiles of each single drug individually. ^ Roger Collier,"Reducing the pill burden", CMAJ February 7, 2012 vol. (Pharmaceutical compounding is the practice of preparing individualized drug products for individual patients, which can aid with polypharmacy.) If an adverse drug reaction occurs from using an FDC, it may be difficult to identify the active ingredient responsible for causing the reaction.
There may not be an FDC available with the appropriate drugs and/or in the most appropriate respective strength(s) for a given patient, which can lead to some patients getting too much of an ingredient and others getting too little, as the AAO notes that FDCs "limit clinicians' ability to customize dosing regimens." In such cases an alternative possibility (instead of an FDC) is to utilize custom-compounded polypills prepared by a compounding pharmacist according to a prescription. Contents 1 Advantages 2 Disadvantages 3 See also 4 References 5 External links . Homepage SlideShare Channels Popular Presentations .. References. In cases of FDCs targeting multiple conditions, such conditions might often be related in order to increase the number of prospective patients who might be likely to utilize a given FDC product. Application Error. ^ Combination Products-U.S. Disadvantages.
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